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My MD put me on Cozaar for my hypertension and rapid pulse. I also take Verapamil. I have a condition called Marfan's Syndrome and Doctor hopes this medicine will help prevent any further dilation of my aorta. I had to go off the hydrochlorothiazide and now have a lot of edema in my legs to above my knees so started on Lasix today also. But it's worth using in order to protect my blood vessels.
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The results reported may not necessarily occur in all individuals.
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.
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They should be evaluated quickly and aggressively with rapid exclusion or treatment of readily reversible causes of hypotension.
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The administration of a non-steroidal anti-inflammatory agent, including a selective cyclooxygenase-2 inhibitor, can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
Closely monitor blood pressure, renal function, and electrolytes in patients on losartan potassium and hydrochlorothiazide tablets and other agents that affect the RAS.
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Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension.
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Hepatic Impairment: Recommended starting dose 25 mg once daily.
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Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
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Dosage adjustments are not necessary in patients with renal impairment unless they are also volume-depleted, in which case therapy should be initiated under medical supervision.
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Losartan potassium was effective in reducing blood pressure regardless of race, although the effect was somewhat less in Black patients (usually a low-renin population).
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Losartan potassium tablets USP, 25 mg are white, round, biconvex film-coated tablets debossed with "II" on one side and plain on other side.
Regular intake of beans in diet can help to keep a check on blood glucose levels.
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These results indicate that aliskiren may provide greater and thus more effective blockade of the renin system in the kidney.
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Clinical trials have demonstrated no rebound hypertension or first-dose orthostatic effect.
CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, Reduction in the Risk of Stroke).
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Uptitration of benazepril or losartan was generally well tolerated in this study.
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While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as that of losartan.
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Goldberg AI, Dunlay MC, Sweet CS "Safety and tolerability of losartan potassium, and angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Subjects who do not metabolize losartan to active metabolite have been shown to have a specific, rare defect in cytochrome P450 2C9.
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National Institutes of Health-funded study comparing treatment with widely used blood pressure medications atenolol or losartan in patients with Marfan syndrome who had an enlarged aortic root found no significant difference in the rate of aortic-root dilation between the two treatment groups over three years.
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