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The administration of a non-steroidal anti-inflammatory agent, including a selective cyclooxygenase-2 inhibitor, can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.

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Losartan potassium tablets USP, 25 mg are white, round, biconvex film-coated tablets debossed with "II" on one side and plain on other side.

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